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One of the newest maternal screening tests is called the quadruple test and is almost identical to the triple screen test. The test involves taking a blood sample and measures a woman's levels of AFP, hCG, estriol and inhibin to indicate the baby's risk of Downs syndrome.

The quadruple test is about 81% effective and is usually performed around the 16th week of pregnancy. If a risk of Downs syndrome is found, amniocentesis can be performed to confirm the diagnosis.

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